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Effect of sub-layer water saturation on two-layer sand fluidization

Doan et al. | Oct 27, 2026

Effect of sub-layer water saturation on two-layer sand fluidization
Image credit: Doan, Damm, and Doan

This study investigates the effect of water saturation in a two-layer fluidization behavior of an overlying dry sand bed. Building on prior work showing that moisture inhibits fluidization in granular media, the authors address an underexplored configuration involving layered dry and wet sand. The experiments demonstrate that even minimal water saturation in the sub-layer prevents uniform fluidization of the dry upper layer, leading to the conclusion that two-layer fluidized beds with moisture are not viable under the conditions tested.

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Investigating the effects of PVC microplastics on the growth of Chlorella vulgaris

Beaubien et al. | Oct 13, 2026

Investigating the effects of PVC microplastics on the growth of <i>Chlorella vulgaris</i>

This study examined the effect of varying PVC microplastic concentrations on the growth of Chlorella vulgaris in freshwater, utilizing six PVC levels and identical culture conditions. Cell counts revealed that higher PVC concentrations consistently reduced algal growth, and a Spearman correlation test detected a significant negative monotonic association between PVC concentration and viable cell density. These results support the hypothesis that PVC microplastics impair algal growth, underscoring their ecological risk in freshwater environments.

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Development of selective RAC1/KLRN inhibitors

Kubrat Neczaj-Hruzewicz et al. | Nov 04, 2024

Development of selective RAC1/KLRN inhibitors

Kalirin is a guanine nucleotide exchange factor (GEF) for the GTPase RAC1, linked to schizophrenia and Alzheimer’s Disease. It plays a crucial role in synaptic plasticity by regulating dendritic spine formation and actin cytoskeleton remodeling, which are essential for creating new synapses. Authors developed two novel compounds targeting kalirin, confirming that predictive modeling can indicate biological activity.

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