The authors use molecular modeling to test analogs of the stearoyl-coenzyme A desaturase 1 (SCD1) inhibitor MF-438 with implications for future development of Parkinson's disease therapeutics.
Read More...Modeling stearoyl-coenzyme A desaturase 1 inhibitors to ameliorate α-Syn cytotoxicity in Parkinson's disease
The authors use molecular modeling to test analogs of the stearoyl-coenzyme A desaturase 1 (SCD1) inhibitor MF-438 with implications for future development of Parkinson's disease therapeutics.
Read More...Transcriptional Regulators are Upregulated in the Substantia Nigra of Parkinson’s Disease Patients
This article investigates differences in gene expression in the brains of patients with and without Parkinson's disease. The authors identify a crucial transcriptional regulator may be a relevant target for future therapeutic treatment for Parkinson's disease.
Read More...Post-Traumatic Stress Disorder (PTSD) biomarker identification using a deep learning model
In this study, a deep learning model is used to classify post-traumatic stress disorder patients through novel markers to assist in finding candidate biomarkers for the disorder.
Read More...Higher pH level increases the efficacy of calcium phosphate-mediated intracellular delivery
This study investigated the impact of pH on the efficiency of calcium phosphate, used as a drug delivery agent.
Read More...Protein kinases in phagocytosis (phagocytotic kinome): A promising biomarker set in cancer therapeutics
This study analyzes genetic alterations and expression patterns of protein kinases involved in phagocytosis across multiple cancers using TCGA data.
Read More...Protein concentrations in cows’ milk during the four stages of lactation
In this article, the authors quantify fluctuations of primary proteins found within bovine milk across four stages of lactation. Critically, these findings bear great relevance to the nutritional support of calves as well as the varying severity of symptoms of lactose intolerance.
Read More...C reactive protein and risk of neurological deficits and disability in patients with acute ischemic stroke
The authors looked at the correlation between C reactive protein levels and neurological deficits in patients who had suffered an ischemic stroke.
Read More...DNA repair protein mutations alter blood cancer sensitivity to cisplatin or gemcitabine in vitro
The authors investigate whether human blood cancers carrying mutations in DNA repair genes possess increased sensitivity to common chemotherapy drugs cisplatin or gemcitabine.
Read More...Reducing levels of C-Reactive Protein: An eight-week, open-label clinical trial of three oral supplements
In this study, the effects of vitamin C, ginger, or curcumin supplements on C-reactive protein levels in healthy participants are determined in an eight-week open-label trial.
Read More...AI-designed mini-protein targeting claudin-5 to enhance blood–brain barrier integrity
The authors employ computational protein design to identify a mini-protein with the potential to enhance binding of the tight junction protein, claudin-5, at the blood-blood barrier with therapeutic potential for neurodegenerative diseases.
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