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Molecular dynamics (MD) simulations are a great tool to model and study complex biological systems. In this paper, the authors use MD simulations to construct and simulate a model of the periplasmic space, the peptidoglycan layer and its associated proteins, in an Escherichia coli cell.

This study, uses SimulATe to model changes in microbial diversity and community structure upon administering a cocktail of antibiotics versus a single antibiotic. The authors hypothesized that antibiotic cocktails, particularly those combining broad-spectrum drugs like tetracyclines and trimethoprims, would cause a more significant reduction in gut microbial diversity compared to single-drug treatments. The findings confirmed a greater loss of microbial diversity with combinatorial treatments compared to single-drug treatments. While individual antibiotics dynamically reshaped the surviving species of the microbiome, antibiotic cocktails frequently cleared all species of the gut microbiome.

The authors test the effects of pH level on different kinds of dental cement to model the long-term effects of reflux-induced stomach acid exposure.

In this study, the authors determine which house model is most resistant to high winds by building smaller prototypes that could be tested with a handheld source of wind.

In this study, the authors developed a model named DNA Sequence Embedding Network (DNA-SEnet) to classify DNA-asthma associations using their genomic patterns.

The authors use MoralBERT, a BERT-based machine learning model, to analyze the prevalence and evolution of moral language in art critique journals from 1960 to 2015. They draw on Moral Foundations Theory to examine changes in five virtue and five vice foundations over time. They discover slight increases in degradation and care and a decrease in purity among otherwise stable patterns. The study is a novel application of computational moral analysis in a domain not typically associated with such tools. Although the moral signals were relatively faint, the study offers insights into shifting art world discourses and models an exciting method for future inquiry.

This study investigates how caffeine and melatonin affect learning in adolescent zebrafish, serving as a model for human teens. Using an automated system to track behavior, we found that melatonin slowed learning while caffeine caused erratic, inconsistent responses, suggesting both substances can negatively impact adolescent learning patterns. These findings highlight the need for further research into their physiological effects and potential implications for human adolescents.

The authors looked at how pharmacokinetics changed depending on the use of an in vitro or an in vivo model.

The authors looked at the impact of different harvest and feeding treatments on Heterandria formosa over three generations as a model for changes in marine ecosystems.

The authors looked at the impacts of short-chain fatty acids on muscle fiber formation as well as insulin sensitivity using a model of mouse myoblasts.